The short answer is no, not in a practical way. Home distillers can achieve a maximum 1 ppm decrease and would require the distillation process to be repeated multiple times to achieve a modest decrease. The freezing method is similarly inefficient. Substantial decrease of deuterium content in water can only be achieved by an industrial scale fractional vacuum distillation technology. Mito DDW contains 84% less deuterium than normal drinking water, whereas home methods alter the deuterium content of water by a mere 1-2%.